| 摘要: |
| 金钗石斛（Dendrobium nobile Lindl.）为兰科（Orchidaceae）石斛属（Dendrobium SW.）植物，具有益胃生津、滋阴清热等功效。药理学研究发现金钗石斛在防治肿瘤、肝硬化、老年痴呆及抗氧化应激损伤等方面具有良好的应用前景。金钗石斛可作为天然抗氧化剂的候选药材，金钗石斛总多酚、总多糖、总黄酮、总生物碱均有不同程度的自由基清除能力。研究发现这些化合物在降低活性氧水平，增强抗氧化酶活性，激活相关抗氧化通路，以及保护蛋白质、DNA、脂质免受氧化损伤等方面具有重要作用。对近年来发表的有关金钗石斛主要活性化合物抗氧化损伤作用的文献进行了综述，旨在为后续金钗石斛的开发应用提供参考。 |
| 关键词: 金钗石斛 活性成分 氧化应激 活性氧 老年痴呆 |
| DOI：10.14188/j.ajsh.2024.03.012 |
| 分类号:R932 |
| 基金项目:贵州石斛产业发展研究中心科研课题（黔石科合2019003-04）；遵义医科大学大学生创新训练项目（ZYDC202202308）；贵州省教育厅-遵义医科大学基础药理教育部重点实验室开放课题（黔教合KY字［2019］049） |
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| Mini review about antioxidant damage effects of Dendrobium nobile |
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LIN Cong, LIU Ziyu, HE Chengfen, SHI Jingshan, LI Fei
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Department of Pharmacology， Guizhou Key Laboratory of Basic Pharmacology， Zunyi Medical University， Zunyi 563000， Guizhou， China
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| Abstract: |
| Dendrobium nobile is a plant of Dendrobium of the orchid family， which has the effects of tonifying stomach and promoting fluid， nourishing “Yin” and clearing “Heat”. Pharmacological studies have shown that Dendrobium nobile has good application prospects in the prevention and treatment of tumor， liver cirrhosis， senile dementia and antioxidative stress damage. Dendrobium nobile can be used as a candidate medicinal material for natural antioxidants， and its total polyphenols， total polysaccharides， total flavonoids and total alkaloids all have different degrees of free radical scavenging ability. These compounds have been found to play an important role in reducing reactive oxygen species level， enhancing antioxidant enzyme activity， activating related antioxidant pathways， and protecting proteins， DNA， and lipids from oxidative damage. In this paper， the literatures on antioxidative damage of main active compounds of Dendrobium nobile published in recent years are reviewed， aiming to provide reference for the subsequent research of Dendrobium nobile. |
| Key words: Dendrobium nobile active compound oxidative stress reactive oxygen species senile dementia |
