| 摘要: |
| 阿尔茨海默病（Alzheimer’s disease，AD）是一种与年龄相关的神经退行性疾病，该疾病的病理特征为老年斑（SPs）和神经原纤维缠结（NFTs）的存在。目前，阿尔茨海默病患病率呈现逐年上升的趋势，寻找完全治愈或延缓阿尔茨海默症发展的有效疗法和药物迫在眉睫。秀丽隐杆线虫（Caenorhabditis elegans）的基因和神经元功能与人类具有高度同源性，可作为研究阿尔茨海默病发病机制研究的较好模型。本文综述AD的发病机制假说、秀丽隐杆线虫AD模型以及线虫模型在AD治疗中的应用进展，旨在为后续研究AD提供理论参考。 |
| 关键词: 阿尔茨海默病 秀丽隐杆线虫 转基因模型 |
| DOI：10.14188/j.ajsh.2023.02.006 |
| 分类号:R749 |
| 基金项目:云南省基础研究计划（昆医联合专项）（2018FE001-309）；云南省教育厅科学研究基金（2023Y0614） |
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| Application of Caenorhabditis elegans model in the study of Alzheimer's disease |
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LI Xinyu1, LI Zihang2, ZOU Zhiyuan2, ZOU Wei1
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1.School of Public Health， Kunming Medical University， Kunming 650500， Yunnan， China;2.Faculty of Basic Medical Sciences， Kunming Medical University， Kunming 650500， Yunnan， China
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| Abstract: |
| Alzheimer’s disease （AD） is an age-related neurodegenerative disease characterized by the presence of senile plaques （SPs） and neurofibrillary tangles （NFTs）. At present， the prevalence rate of Alzheimer’s disease shows an increasing trend year by year. It is urgent to find effective therapies and drugs to completely cure or delay the development of Alzheimer’s disease. The gene and neuronal function of Caenorhabditis elegans are highly homologous with humans， and can be used as a good model to study the pathogenesis of Alzheimer’s disease. In this paper， the pathogenesis hypothesis of AD， the AD model of Caenorhabditis elegans and the application progress of the nematode model in the treatment of AD are reviewed， aiming to provide theoretical reference for the subsequent research on AD. |
| Key words: Alzheimer’s disease（AD） Caenorhabditis elegans transgenic model |
