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| 链激酶研究概况及其进展 |
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张华山1,闫俊鹏2,齐义鹏2,李亚芳1,余响华1
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1. 湖北工业大学生物工程学院,武汉,430068;2. 武汉大学生命科学学院,武汉,430072
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| 摘要: |
| 链激酶(Streptokinase,SK)是世界上最早发现的纤维蛋白酶原激活剂,也是最早作为临床药品治疗血栓性疾病的溶栓酶.它是由A,C,G群链球菌中β-溶血性链球菌分泌的胞外非酶蛋白质,能和纤溶酶原结合,将纤溶酶原激活为纤溶酶,具有溶解血栓的作用.本文详细综述了该酶的性质、在溶栓酶中的地位、研究历史、作用机理等.此外,由于它有半衰期短、不具有纤维蛋白特异性、治疗后出血和血栓易复发的缺点,所以有必要用基因工程的手段进行改造,以达到更好的治疗效果. |
| 关键词: 链激酶 重组链激酶 纤溶酶原 |
| DOI： |
| 分类号:Q936 |
| 基金项目: |
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| General Situation and Latest Progress on Streptokinase |
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| Abstract: |
| Streptokinase(SK) was discovered as the first plasminogen activator in the world,and it was the earliest clinical agent to cure thrombus.Streptokinase is an extracellular protein which is produced by β-hemolytic streptococci group A,C and G.It binds to plasminogen(Pg) to form a complex that converts substrate Pg to plasmin.And it can lyse blood clots.We summarized the characteristics、status、research history、catalytic mechanism of it.In addition,Because of its short half-life、bleeding、non fibrin-specific and recurring rate,it is necessary to reconstruct it by gene engineering to obtain better curative effect. |
| Key words: streptokinase recombinant streptokinase plasminogen |
