| 摘要: |
| 多肽的合成方法很多,传统的方法有混合酸酐法、活泼酯法和偶联试剂法,本文采用酰氯法,以L-缬氨酸为原料,经过酰化、氨解形成二肽,二肽再经过酰化、氨解最终形成三肽.通过对三肽样品的红外、核磁及高效液相等的鉴定说明该方法实验步骤简单,原料易得,收率很高,很适合于工业化生产,目前国内尚无文献报道. |
| 关键词: 三肽 酰化 氨解 |
| DOI： |
| 分类号:TQ464.7 |
| 基金项目: |
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| Synthetic Study of Glycyl-Glycyl-Valine Tripeptide Using The Way of Acyl Chloride |
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| Abstract: |
| There are many ways to prepare polypeptide, such as mixed anhydride, active ester and couple agent. We prepared tripeptide using the way of acyl chloride. We got dipeptide by means of valine acylation and aminolysis, and then got tripeptide. We investigate the sample by FT-IR, HNMR and HPLC. This experiment has some advantages such as easy operation, high yield and easy to industrialization. |
| Key words: tripeptide acylation aminolysis |
